The 10 people shot included five men and five women, the police department said in a series of tweets.
Two of the men died and another man was at a hospital in critical condition, police said. The other seven wounded people had injuries not considered to be life-threatening.
No arrests were immediately announced.
Police spokesperson John Elder said the gunfire stemmed from two men in a crowd who got into an argument, pulled out guns and started shooting, KMSP-TV reported.
This is a developing story.